According to emerging evidence, rhythmic processing (e.g., beat synchronization) plays a critical role in phonological encoding and decoding; to the extreme, deficits in the former processing manifest as dyslexia and the latter as stuttering. In a recent fMRI-genetic study, we demonstrated that both behavioral and neural differences in rhythm/timing processing were influenced by a DRD2 polymorphism (Wiener, Lee, Lohoff, & Coslett, 2014). A similar fMRI-genetic study revealed that DRD2 polymorphism caused poor grammar sequence learning and reduced activity in the basal ganglia (Wong, Ettlinger, & Zheng, 2013). Here, we will first establish direct relations between music and speech/language processes within the same individuals prior to fMRI-genetic studies.
Sanghoon Ahn, Ian Goldthwaite, Kate Corbeil, Allison Bryer, Korrin Perry, Aiesha PolaKampalli, Katherine Miller, Rachael Holt & Yune S. Lee (2017) Wiener, M., Lee, Y.-S., Lohoff, F. W., & Coslett, H. B. (2014). Individual differences in the morphometry and activation of time perception networks are influenced by dopamine genotype. NeuroImage, 89, 10–22.
This study aims to investigate the neural activities that likely undergo substantial changes after Cochlea Implant (CI) surgery in either pre- or post-lingual deaf patients. Patients’ neural correlates of speech comprehension will be measured using a portable neuroimaging device, fNIRS, in the following timelines: 3, 6, and 12 months after the CI. To the best of our knowledge, this is the first longitudinal study of CI patients using the fNIRS.
Aaron Moberly, MD (Dept. of Otolaryngology)
Shimadzu Equipment Grants for Education & Research (awarded $72.5k)
Planning to submit the proposal to The Therapeutic Development Program under The Dorothy E. Ann Fund (D.E.A.F.) administered by the Columbus Foundation (TCF), which focuses on support to organizations serving children and youth who are deaf or hard of hearing. Applications are due on December 15th, 2017.
A growing body of evidence shows positive effects of music and dance activities on PD patients’ emotional, language, and motoric processes. This project aims to investigate dopamine modulation within the basal ganglia of PD patients through music/dance-based rehabilitation programs.
Michael Knopp, MD/Ph.D. (Director, Wright Center of Innovation in Biomedical Imaging)
Michael Thaut, Ph.D (Director, Music and Health Research Collaboratory, University of Toronto)
The Michael J. Fox Foundation Therapeutic Pipeline Program (submitted on Sept. 27, 2017)
Successful academic activities of school-age children rely on efficient speech and language processing. Although 10-15% of children are diagnosed with some type of speech/language disorder (dyslexia, specific language impairment, etc.), there are likely many children with speech/language deficiencies that are on the borderline of the pathologic range or are within it but lack the diagnostic resources to identify such deficits. Through community partnerships with the Columbus City Schools, we aim to 1) offer brain-based diagnostic opportunities to these children vulnerable to academic failure in the Ohio school system, 2) provide them with music-based intervention programs that will promote brain regions mediating overlapping processes between music and language, and 3) establish neural foundations of brain plasticity following behavioral improvement with a state-of-the-art portable neuroimaging device (i.e., functional near-infrared spectroscopy, fNIRS). This project will constitute the first step towards making a valuable contribution to the Ohio education community, as well as to the neuroscience research field.
Eugenia Costa-Giomi, Ph.D. (School of Music)
Betty Hills, Arts Supervisor of CCS (Columbus City Schools)
Shayne B. Piasta, Ph.D. (Department of Teaching & Learning)
Shimadzu Equipment Grants for Education & Research (recieved $72.5k in April, 2017)
Autumn 2017 Connect and Collaborate Grants (due 9/29)
The Endowment of Art Works Foundation (due 10/27)
This interdisciplinary research program aims to bridge the gap between rehabilitation and neuroscience by elucidating a hitherto unknown neural mechanism, i.e., compensatory brain plasticity leading to speech/language recovery following rhythm-based therapy with state-of-the-art neuroimaging and video game technology.
Lee et al. Patterns of neural activity predict picture-naming performance of a patient with chronic aphasia. Neuropsychologia 94(2017) 52-60.
Lynne Gauthier, Ph.D. (Department of Physical Medicine & Rehabilitation)
Roger Crawfis, Ph.D. (Department of Computer Science and Engineering)
Stacy Harnish, Ph.D. (Department of Speech and Hearing Science)
Michael Torbey, MD (Department of Neurology)
Deepak Gulati, MD (Department of Neurology)
Chronic Brain Injury Pilot Award Program (received $50k on Dec. 8th 2016)
Beckman Young Investigators Program (submitted on Aug. 4th 2017)